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| Beriberi |
Beriberi
Wet beriberi =high cardiac output failure.Dry beriberi =type of peripheral neuropathy.
Wet beriberi
1) oriental beriberi caused by eating diets in which most calories r derived 4m polished,highly milled rice.
2) oedema=caused by metabolites like pyruvate nd lactate which cause extreme peripheral vasodilatation nd leakage of fluid 4m capillaries.
3) beriberi heart disease charactorised by =
-peripheral vasodilatation
-high cardiac output state with warn extremities.
-biventricular failure.
-retention of Na nd water.
-extreme tachycardia.
-venous congestive state charactorised by raised jvp nd tender hepatomegaly.
-hyperdynamic circulation.
-dyspnoea
-cardiomegaly.
BIOCHEMICAL TESTS
1)measurement of bld thiamine,pyruvate nd lactate levels.
2)whole bld or erythrocyte transketolase activity.
MANAGEMENT
1)complete bed rest.
2)100 mg thiamine IM 4 fist 7 days, then 10 mg/day orally 4 several months.
DRY BERIBERI
1)nutritional polyneuropathy is charactorised by symmetric impairement of sensory,motor nd reflex functions dat affect distal segments of limbs more severly dan proximal ones.
2)histology= non inflamatory degeneration of myelin sheaths.
3) 3 types of nervous system involved in beriberi.
- peripheral neuropathy.
- cerebral beriberi
- Korsakoffs syndrome.
INFANTILE BERIBERI
seen in breast feed infants of thiamine deficent mothers.Usual age of onset is 2-3 months.
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