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| Aquired aplastic anaemia |
Aquired aplastic anaemia
Causes-drugs like chloramphenicol,oxyphenbutazone,sulfonamides,cimetidine,phenytoin,carbamazepine.Exposure to ionising radiatn..,.Infections -parvovirus,hepatitis b,c,d,EB virus...Chemicals lik DDT,benzene,aromatic hydrocarbons..Metals like-gold,arsenic,lead..CLINICAL features-progressive anaemia,asscwith weakness nd easy fatigability.Patechiae,ecchymosis,mucosal bleeding,bleeding frm gut,hematuria,haemorrhage, luecopenia nd neutropenia leads to recurrent Rs nd GIT Infectn..Hedache,irratibility,nd neurological deficit suggest intracranial bleed due to thrombocyto penia..LAB investigatn-blood picture-pancytopenia,low reticulocyte count,incrd serum iron,decrd iron binding capacity..Bone marrow aspiratn-dry..Bone biopsy:hypocellular...D.Ds:idiopathic throbocytopenic purpura,Leukemia,Myeloid metaplasia..TREATMENT:A..SUPPORTIVE care:1..platelets supplement to prevent bleeding..2...Control of infectiös 3...Aseptic measures to prevent infectn.4..Treat infect with _cephalosporine,aminoglycosides,metronidaxol..5..Red cell transfusion.. B...Definitive tierapy:1., Bone marrow transplantatn..2..Immuno therapy=antilymphocyte globulin(ALG),antithymocyte globlin(ATG) nd cyclosporin
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