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| Amoebic dysentry |
Amoebic dysentry
AMOEBIC DYSENTRY= PATHOGENESIS- 1- it results 4m infection of large intestine by Entamoeba histolytica. 2-caused by ingestion of tetra-nucleated cysts. 3-after ingestion cysts undergo further nuclear division n eight trophozoites r released in terminal ileum. Later they carried to large intestine n produse 'flask shaped' amoebic ulcerations. 4-Incubation period 2-6 wks. CLINICAL FEATURES= 1-intesmittent diarrhoea 1-4, foul smelling, loose, watery stools wid mucus n blood. 2-flatulence n abdominal cramping r frequent..3-fever occur sometimes. 4-tender hepatomegaly n tenderness over caecum, ascending colon, left iliac fossa.. COMPLICATIONS= 1-massive haemorrhage. 2-perforation n peritonitis. 3-toxic megacolon. 4-localised granuloma. 5-amoebic liver abscess. 6- amoebic pericarditis. DIAGNOSIS= 1-stool examination show motile trophozoites. 2-sigmoidoscopy, reveal flask shaped ulcers. 3-amoebic serologic tests= indirect haemagglutination test, ELISA, 4- chest radiography 5-ultrasound for amoebic liver abscess. TREATMENTA= 1- metronidazole 800 mg thrice daily for 5 days. Or 2- tinidazole 2 g daily as single dose for 3 days. 3- after treatment furamide 500 mg thrice daily for 10 days. 4- iodoquinol n paromomycin r alternatives.
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