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| Ca breast etiology |
Ca breast etiology
Atiologcal factor_
1 it is rare below the age of20.The highest incidence is found bet 40-60 yrs of age.2 breast ca. N syndrme-
a Li-fraumeni syndrome
b cowden disease
c ataxia telangiectasia.
3 chromosomal abnormalities hv been found in short arm of chromosome 17 in women with a family history of ca breast.BRCA-1 n BRCA-2 r the genes associated increased risk.
4 Diet-increased risk has bee found in postmenopausal wome n is due to increase synthesis of oestrogen in the body fat.Alcohol intake is associated with 1.5 increased risk of ca breast.Vit C may hv protective value.Increase intake of saturated fats n reuduce intake of phytooestroge increases risk.
5 endocrine cause_
a longer the cumulative period of menstruation more the risk
b more the cumulative period of lactation better the protection.
C more abortions n each occurin later increases risk.
D more oestrogen content in OCP n OCP taken early in the reproductive life increases risk.
E HRT increases risk if the oestrogen content is higher n if taken for more than 5 yrs.
6 female sex itself is a risk factor .
7 Geogrophical_
ca breast is a disease of white,western women. It is rare in Japan n Taiwan.
Structure remove in patey mastectomy_
entire breast including areaola n nipple r removed with pectoralis minor followed by axillary block dissection.
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