Analgesic nephoropathy

Analgesic nephoropathy

Analgesic Nephoropathy

 Heavy use of amalgesic mixture of phenacetin in combination with aspirin acetaaminophen
Morphology
 papillary necrosis
 tubulo interstetial infalmation
damage to vascular supply of inner medulla lead to local intersti inflam reaction
 
c/f          
proteinuria
hematuria
pyuria
renal coli
nephrocalcinosis

invest

urine -proteinuria
     hematuria
     pyuria

IPV
 ring sign

CT
 gasRland paTERN

TREATMENT
discourage use of this combinatio n phenactin