Amoebic dysentry

Amoebic dysentry

Amoebic dysentry

AMOEBIC DYSENTRY= PATHOGENESIS-     1- it results 4m infection of large intestine by Entamoeba histolytica.  2-caused by ingestion of tetra-nucleated cysts.  3-after ingestion cysts undergo further nuclear division n eight trophozoites r released in terminal ileum. Later they carried to large intestine n produse 'flask shaped' amoebic ulcerations. 4-Incubation period 2-6 wks.     CLINICAL FEATURES= 1-



intesmittent diarrhoea 1-4, foul smelling, loose, watery stools wid mucus n blood.      2-flatulence n abdominal cramping r frequent..3-fever occur sometimes. 4-tender hepatomegaly n tenderness over caecum, ascending colon, left iliac fossa..  COMPLICATIONS= 1-massive haemorrhage. 2-perforation n peritonitis. 3-toxic megacolon. 4-localised granuloma. 5-amoebic liver abscess. 6- amoebic pericarditis. DIAGNOSIS= 1-stool examination show motile trophozoites. 2-sigmoidoscopy, reveal flask shaped ulcers. 3-amoebic serologic tests= indirect haemagglutination test, ELISA,  4- chest radiography 5-ultrasound for amoebic liver abscess. TREATMENTA= 1- metronidazole 800 mg thrice daily for 5 days. Or 2- tinidazole 2 g daily as single dose for 3 days.  3- after treatment furamide 500 mg thrice daily for 10 days. 4- iodoquinol n paromomycin r alternatives.